Immunohistochemical detection of proliferating cell nuclear antigen in hepatocellular carcinoma
نویسندگان
چکیده
منابع مشابه
Immunohistochemical Analysis of Progesterone Receptor and Proliferating Cell Nuclear Antigen in Canine Inflammatory Mammary Carcinoma
Cancer constitutes a major problem in animal pathology and is a subject of intensive research. Canine mammary tumors are common neoplasms and have been reported to account for up to half of all tumors in female dog [1]. All malignant canine mammary tumors have the potential to metastasize and in general, metastasis tends to occur via the lymphatic system to the inguinal lymph nodes or hematogen...
متن کاملPrognostic value of proliferating cell nuclear antigen in gastric carcinoma.
A new monoclonal antibody to proliferating cell nuclear antigen (PCNA), PC10, which can be used on routinely processed tissue, was applied to 93 cases of gastric carcinoma. Significant intra-tumoural variation in staining occurred. In addition to a PCNA index (percentage of positive cells per 1000 tumour cells), a semiquantitative PCNA grading system was devised, based on estimates of less than...
متن کاملProliferating cell nuclear antigen (PCNA) activity in hepatocellular carcinoma, benign peri-neoplastic and normal liver.
Hepatocellular carcinoma (HCC) is among the ten most common cancers in Malaysian males. As cellular proliferation is an important feature of malignant transformation, we studied the proliferation pattern of normal and benign perineoplastic liver versus hepatocellular carcinoma in an attempt to further understand the tumour transformation process. 39 HCC (21 with accompanying and 18 without cirr...
متن کاملProliferating cell nuclear antigen expression in papillary thyroid carcinoma.
AIMS To correlate the expression of proliferating cell nuclear antigen (PCNA) with various clinicopathological features of papillary thyroid carcinoma. METHODS Sections from 131 formalin fixed, paraffin wax embedded papillary thyroid carcinomas were stained with a monoclonal antibody (PC10) directed against PCNA using the avidin-biotin immunoperoxidase (ABC) method. PCNA immunoreactivity was ...
متن کاملProliferating Cell Nuclear Antigen (PCNA) in Prostatic Carcinoma
Proliferating cell nuclear antigen (PCNA) is an auxiliary protein of DNA • @polymerase-• Ý • @ that • @is • @ synthesized • @ during • @ the • @ late • @G1 • @ phase through the S phase of cell proliferation. The expression of PCNA correlates strongly with cell proliferation. In the present study, employing NC-012, which is an anti-human PCNA monoclonal antibody, we performed immunohistochemica...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2011
ISSN: 1007-9327
DOI: 10.3748/wjg.v3.i2.101